Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies†
Fabio
Travagin, 
b
Giovanni B.
Giovenzana,
b
Sophia
Lotti,
a
Federico
Maisano,
a
Miles A.
Kirchin,
a
Alice
Giorgini,
a
Zsolt
Baranyai
*a
b
Giovanni B.
Giovenzana,
b
Sophia
Lotti,
a
Federico
Maisano,
a
Miles A.
Kirchin,
a
Alice
Giorgini,
a
Zsolt
Baranyai
*a
Abstract
The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.
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