Issue 2, 2020

A self-emulsifying formulation of Sonchus oleraceus Linn for an improved anti-diabetic effect in vivo

Abstract

The aim of the present study was to develop a self-emulsifying drug delivery system (SEDDS) containing the extract of S oleraceus Linn (SOL) with improved intestinal stability in order to increase oral bio-potency. SOL was effectively incorporated into emulsions, which showed resistance to in vitro digestion without any destruction of its phenolic acids, glycosides and aglycone. SEDDS and SOL were also prepared for the comparison of in vivo anti-diabetic effects. Four weeks of daily treatments of SEDDS dramatically improved the quality of life for diabetic rats. Streptozotocin (STZ) caused body weight reduction, which was reversed by SEDDS at a low dose (100 mg kg−1), and it was more effective than SOL at a high dose (200 mg kg−1). SEDDS also improved the response to glucose tolerance, which was significantly higher than that of SOL. On the basis of these findings, the SEDDS approach might be an efficacious dosage option to enhance the nutraceutical properties of SOL.

Graphical abstract: A self-emulsifying formulation of Sonchus oleraceus Linn for an improved anti-diabetic effect in vivo

Supplementary files

Article information

Article type
Communication
Submitted
15 Apr 2019
Accepted
13 Dec 2019
First published
17 Dec 2019

Food Funct., 2020,11, 1225-1229

A self-emulsifying formulation of Sonchus oleraceus Linn for an improved anti-diabetic effect in vivo

L. Chen, X. Lin, X. Fan, Q. Lv, H. Fang, Y. Chenchen and H. Teng, Food Funct., 2020, 11, 1225 DOI: 10.1039/C9FO00772E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements