Issue 1, 2020
From the journal:

Green Chemistry

The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions†

Qing-Wen Gui,a   Xiaoli He,a   Wenjing Wang,a   Huilin Zhou,a   Yumei Dong,a   Nengqing Wang,a   Jia-Xi Tang,b   Zhong Cao ORCID logo c  and  Wei-Min He ORCID logo *c  

* Corresponding authors

a College of Science, Hunan Agricultural University, Changsha, China

b School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China

c Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha, China
E-mail: weiminhe2016@yeah.net

Abstract

A practical and sustainable protocol for the clean preparation of various multisubstituted pyrroles through an iodine-catalyzed multicomponent reaction under metal- and solvent-free conditions was developed. In the gram-scale synthesis, the desired pyrroles can be easily isolated in high-purity through simple extraction.

Graphical abstract: The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C9GC02657F
Article type
Paper
Submitted
29 Jul 2019
Accepted
21 Oct 2019
First published
29 Nov 2019

Green Chem., 2020,22, 118-122

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The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions

Q. Gui, X. He, W. Wang, H. Zhou, Y. Dong, N. Wang, J. Tang, Z. Cao and W. He, Green Chem., 2020, 22, 118 DOI: 10.1039/C9GC02657F

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