Continuous flow Suzuki–Miyaura couplings in water under micellar conditions in a CSTR cascade catalyzed by Fe/ppm Pd nanoparticles†
Alex B.
Wood, 
*a
Kakasaheb Y.
Nandiwale,
*b
Yiming
Mo,
b
Fabrice
Gallou,
c
Klavs F.
Jensen
*b
and
Bruce H.
Lipshutz
*a
*a
Kakasaheb Y.
Nandiwale,
*b
Yiming
Mo,
b
Fabrice
Gallou,
c
Klavs F.
Jensen
*b
and
Bruce H.
Lipshutz
*a
Abstract
The first demonstration of aqueous surfactant-enabled Suzuki–Miyaura couplings run under flow conditions is described. In addition, use of an even more challenging heterogeneous nanoparticle catalyst, containing only 800 ppm of Pd (i.e., 0.08 mol%) in the form of Fe/ppm Pd nanoparticles, is sufficient using a continuous stirred-tank reactor (CSTR).
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