Issue 16, 2020

Electrochemical synthesis of sulfonamides in a graphite powder macroelectrode

Abstract

The electrochemical generation of sulfinyl radicals from commercially available and non-expensive sodium salts of sulfinic acids is described. Electrooxidation reactions were carried out in a graphite powder macroelectrode using an aqueous electrolyte and cavity cell. Further reaction with primary or secondary amines gave the corresponding sulfonamides, a unit present in several biologically active compounds and pharmaceuticals, in good yields.

Graphical abstract: Electrochemical synthesis of sulfonamides in a graphite powder macroelectrode

Supplementary files

Article information

Article type
Communication
Submitted
17 Apr 2020
Accepted
16 Jul 2020
First published
17 Jul 2020

Green Chem., 2020,22, 5262-5266

Electrochemical synthesis of sulfonamides in a graphite powder macroelectrode

D. A. Vicente, D. Galdino, M. Navarro and P. H. Menezes, Green Chem., 2020, 22, 5262 DOI: 10.1039/D0GC01360A

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