Issue 4, 2020

Controlling the block sequence of multi-block oligomer ligands for neutralization of a target peptide

Abstract

A series of block oligomers consisting of the same monomer composition but a different block sequence was prepared via reversible addition–fragmentation chain transfer (RAFT) polymerization to screen high affinity ligands for a toxic peptide. Activity and affinity screening of mono-, di-, and tri-block oligomers revealed that in addition to the localization and combination of functional groups, the sequence of the functional block and end groups are of significant importance to design the ligands that bind and neutralize the peptide.

Graphical abstract: Controlling the block sequence of multi-block oligomer ligands for neutralization of a target peptide

Supplementary files

Article information

Article type
Communication
Submitted
31 Mar 2020
Accepted
30 Jun 2020
First published
30 Jun 2020
This article is Open Access
Creative Commons BY license

Mater. Adv., 2020,1, 604-608

Controlling the block sequence of multi-block oligomer ligands for neutralization of a target peptide

H. Takimoto, S. Katakami, Y. Miura and Y. Hoshino, Mater. Adv., 2020, 1, 604 DOI: 10.1039/D0MA00149J

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