Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications†
Eduardo V.
Silveira, 
*a
Eduardo H.
Wanderlind,
‡a
Andrieli K.
Masson,
a
Pâmella S.
Cordeiro,
b
Vanessa
Nascimento,
b
*a
Eduardo H.
Wanderlind,
‡a
Andrieli K.
Masson,
a
Pâmella S.
Cordeiro,
b
Vanessa
Nascimento,
b
Abstract
The molecular recognition of the carboxylatopillar[5]arene on methamphetamine showed interconversion between H2:G ![[leftrightharpoons]](https://www.rsc.org/images/entities/char_21cb.gif)
H:G stoichiometries with dependence on drug concentration. The study simulated conditions of severe metabolic acidosis (pH 7.00) and presented intelligent and promising dynamics for the removal of overdosed drugs or poisons in the circulatory system.
![Graphical abstract: Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9NJ06213K&imageInfo.ImageIdentifier.Year=2020)
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