The simple design of a new recyclable magnetic carbon graphite adsorbent based on 2-amino-5-mercapto-1,3,4-thiadiazole for the fast extraction of two anti-depressant drugs

Abstract

In this work, an efficient magnetic nanoadsorbent, cubic SnFe₂O₄/graphitic carbon nitride (g-C₃N₄) modified by 2-amino-5-mercapto-1,3,4-thiadiazole (AMT), was synthesized. The successful modification of the g-C₃N₄ surface with SnFe₂O₄ and AMT was verified by FT-IR, XRD, FE-SEM, EDX, and VSM analyses. The g-C₃N₄/cubic SnFe₂O₄–AMT composite was used as an effective nanoabsorbent for the determination of the drugs amitriptyline (ATP) and imipramine (IMP) from a blank urine sample using an ultrasound-assisted magnetic dispersive micro solid-phase extraction method. The analytes were detected using high-performance liquid chromatography. The optimal adsorption and desorption conditions were determined using the central composite experimental design method. Under the optimal conditions, limits of detection of 2.0 and 0.7 μg L⁻¹ and relative standard deviation values (n = 5) of 1.6% and 6.7% were obtained for ATP and IMP, respectively, and the linear dynamic range was 2.0–6000.0 μg L⁻¹.