Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

Abstract

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona. In this study, poly(carboxybetaine methacrylate) (pCBMA) coating was used for MMSNs because pCBMA inhibits protein uptake. Tamoxifen is loaded onto magnetite mesoporous silica nanoparticles and then embedded in pCBMA nanogels. The drug release was studied for 125 h at temperatures of 37 and 43 °C and pH values of 6.7 and 7.4. Our results show that less than 20% of the drug is released within 24 hours for all samples. MTT assay was performed to determine the biocompatibility of the nanogels. The results show that nanogels are biocompatible at high concentrations. The growth and proliferation of L929 cells after 72 hours were studied. In this study, hyperthermia (in vitro) was investigated and the nanogels showed good heat production capability.