Issue 21, 2020

Iodine-catalyzed α,β-dehydrogenation of ketones and aldehydes generating conjugated enones and enals

Abstract

A transition metal-free α,β-dehydrogenation of ketones and aldehydes was developed. This reaction was conducted in a facile I2/KI/DMSO system to produce the corresponding unsaturated compounds in good to high yields. The gram-scale experiment also indicated the potential synthetic value of this new reaction in organic synthesis. In the reaction, DMSO acted as both solvent and mild oxidant.

Graphical abstract: Iodine-catalyzed α,β-dehydrogenation of ketones and aldehydes generating conjugated enones and enals

Supplementary files

Article information

Article type
Letter
Submitted
12 Mar 2020
Accepted
01 May 2020
First published
04 May 2020

New J. Chem., 2020,44, 8697-8701

Iodine-catalyzed α,β-dehydrogenation of ketones and aldehydes generating conjugated enones and enals

Y. Cao, L. Liu, T. Huang and T. Chen, New J. Chem., 2020, 44, 8697 DOI: 10.1039/D0NJ01244K

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