Issue 9, 2020

Direct silica coating of drug crystals for ultra-high loading

Abstract

To push the limit of synthetic control, we create a thin layer (5 nm) of silica on the surface of drug nanocrystals, achieving a loading content (88%) that approaches the theoretical limit. The uniform silica shell provides a tailored diffusion barrier for controlled drug release. The method can be generally applied to 11 organic crystals, including 4 drugs.

Graphical abstract: Direct silica coating of drug crystals for ultra-high loading

Supplementary files

Article information

Article type
Communication
Submitted
03 Dec 2019
Accepted
09 Feb 2020
First published
10 Feb 2020

Nanoscale, 2020,12, 5353-5358

Direct silica coating of drug crystals for ultra-high loading

N. Wang, W. Zhou, M. Yan, M. Zhang, H. Wang and H. Chen, Nanoscale, 2020, 12, 5353 DOI: 10.1039/C9NR10225F

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