A near-infrared light-mediated antimicrobial based on Ag/Ti3C2Tx for effective synergetic antibacterial applications

Xiaoquan Zhu; Yingnan Zhu; Ke Jia; Bahreselam Sielu Abraha; Yang Li; Wenchao Peng; Fengbao Zhang; Xiaobin Fan; Lei Zhang

doi:10.1039/D0NR04925E

A near-infrared light-mediated antimicrobial based on Ag/Ti₃C₂T_x for effective synergetic antibacterial applications†

Xiaoquan Zhu,‡^a Yingnan Zhu,‡^b Ke Jia,^b Bahreselam Sielu Abraha,

^a Yang Li,

^a Wenchao Peng,

^a Fengbao Zhang,^a Xiaobin Fan

*^a and Lei Zhang

*^b

Author affiliations

* Corresponding authors

^a School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China
E-mail: xiaobinfan@tju.edu.cn

^b School of Chemical Engineering and Technology, Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), Tianjin University, Tianjin 300072, People's Republic of China
E-mail: lei_zhang@tju.edu.cn

Abstract

Designing antimicrobials with high efficiency and long-term antibacterial activity is an imperative issue. We found that the antimicrobial effect of Ti₃C₂T_x and Ag/Ti₃C₂T_x could be significantly strengthened upon near-infrared light exposure. The synergistic antibacterial mode of the photothermal bactericidal effect and intrinsic bacterial activity have been revealed, which confirms that the Ti₃C₂T_x MXene is an excellent near-infrared light-mediated nanoplatform for antibacterial applications. To further test the antibacterial effect in practical applications, Ag/Ti₃C₂T_x embedded hydrogels were used as wound dressings in a wound model experiment. They exhibit outstanding bacterial inhibition and wound healing performance with near-infrared light exposure. This work inspires us to explore the MXene-based photothermal platform in terms of antibacterial application.

This article is part of the themed collection: 2020 Nanoscale HOT Article Collection

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Article information

DOI: https://doi.org/10.1039/D0NR04925E
Article type: Paper
Submitted: 30 Jun 2020
Accepted: 17 Jul 2020
First published: 10 Aug 2020

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Nanoscale, 2020,12, 19129-19141

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A near-infrared light-mediated antimicrobial based on Ag/Ti₃C₂T_x for effective synergetic antibacterial applications

X. Zhu, Y. Zhu, K. Jia, B. S. Abraha, Y. Li, W. Peng, F. Zhang, X. Fan and L. Zhang, Nanoscale, 2020, 12, 19129 DOI: 10.1039/D0NR04925E

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