K2S2O8-HFIP synergistically promoted para-selective sp3 C–H bond diarylation of glycine esters

Abstract

A metal-free K₂S₂O₈-HFIP synergistically promoted double Friedel–Crafts alkylation between a glycine derivative and N-substituted aniline was developed to efficiently synthesize diarylmethane derivatives with high para-selectivity. The reaction proceeded smoothly in the absence of any metal and ligand, and exhibited a good tolerance of functional groups.