Issue 8, 2020
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 3-acylindoles via copper-mediated oxidative decarbethoxylation of ethyl arylacetates†

Anjali Jaiswal,a   Anup Kumar Sharmaa  and  Krishna Nand Singh ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India
E-mail: knsingh@bhu.ac.in, knsinghbhu@yahoo.co.in

Abstract

An efficient regioselective C-3 acylation of free indoles (N–H) has been accomplished via oxidative decarbethoxylation of easily available ethyl arylacetates using Cu(OAc)2 and KOtBu in DMSO.

Graphical abstract: Synthesis of 3-acylindoles via copper-mediated oxidative decarbethoxylation of ethyl arylacetates

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Article information

DOI
https://doi.org/10.1039/C9OB02550B
Article type
Paper
Submitted
28 Nov 2019
Accepted
03 Feb 2020
First published
03 Feb 2020

Org. Biomol. Chem., 2020,18, 1623-1628

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Synthesis of 3-acylindoles via copper-mediated oxidative decarbethoxylation of ethyl arylacetates

A. Jaiswal, A. K. Sharma and K. N. Singh, Org. Biomol. Chem., 2020, 18, 1623 DOI: 10.1039/C9OB02550B

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