Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria†
Hadyn L.
Parker, 
a
Ruben M. F.
Tomás,
b
Christopher M.
Furze,
a
Collette S.
Guy
ab
and
Elizabeth
Fullam
*a
a
Ruben M. F.
Tomás,
b
Christopher M.
Furze,
a
Collette S.
Guy
ab
and
Elizabeth
Fullam
*a
Abstract
The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.
- This article is part of the themed collections: Chemical Biology in OBC and Glycosylation: New methodologies and applications
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