A mild catalytic modification of dihydropyrrolo[2,1-a]isoquinolines with various phenols via the formation of heteroarene cation radicals as key intermediates has been developed. A range of direct cross-coupling products could be obtained in acceptable to excellent yields (up to 98%) in the presence of FeCl2.
![Graphical abstract: FeCl2 catalyzed direct modification of dihydropyrrolo[2,1-a]isoquinolines with phenols](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D0OB00917B&imageInfo.ImageIdentifier.Year=2020)
H. Cui, Org. Biomol. Chem., 2020, 18, 4085 DOI: 10.1039/D0OB00917B
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