Tandem Prins cyclizations for the construction of oxygen containing heterocycles

Abstract

Tandem Prins cyclization is a versatile method for the synthesis of fused/bridged/spirotetrahydropyran scaffolds. Therefore, it has become a powerful tool for the stereoselective synthesis of oxygen/nitrogen containing heterocycles. Indeed, previous review articles on Prins spirocyclization illustrate the synthesis of spirotetrahydropyran derivatives and the aza-Prins reaction demonstrates its application in the total synthesis of natural products. The current review is devoted specifically to highlight tandem Prins cyclizations for the construction of fused scaffolds and related frameworks with a particular emphasis on recent applications. The mechanistic aspects and the scope of the methods are briefly discussed herein.