Iridium-catalyzed direct C–H arylation of cyclic N-sulfonyl ketimines with arylsiloxanes at ambient temperature

Abstract

An iridium-catalyzed ortho-selective C–H arylation of cyclic N-sulfonyl ketimines has been achieved with environmentally benign aryl siloxanes. The reaction is highly efficient and proceeds at ambient temperature which is the key feature of the methodology considering the weak coordination nature of the substrate as well as the sluggish reactivity of siloxanes. A wide array of pharmaceutically relevant novel biaryls has been synthesized under operationally simple conditions.