Issue 31, 2020
From the journal:

Organic & Biomolecular Chemistry

On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments†

Zhiyang Quana  and  Jeroen S. Dickschat ORCID logo *a  

* Corresponding authors

a Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany
E-mail: dickschat@uni-bonn.de
Tel: +49 228 735797

Abstract

An ophiobolin F synthase homolog was discovered from Aspergillus calidoustus CBS121601. The cyclisation mechanism of this terpene synthase was investigated by extensive isotopic labelling experiments and the absolute configuration of its product ophiobolin F was elucidated by enantioselective deuteration.

Graphical abstract: On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments

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Article information

DOI
https://doi.org/10.1039/D0OB01470B
Article type
Communication
Submitted
16 Jul 2020
Accepted
25 Jul 2020
First published
27 Jul 2020

Org. Biomol. Chem., 2020,18, 6072-6076

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On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments

Z. Quan and J. S. Dickschat, Org. Biomol. Chem., 2020, 18, 6072 DOI: 10.1039/D0OB01470B

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