Issue 35, 2020
From the journal:

Organic & Biomolecular Chemistry

Synthesis of indoline-fused eight-membered azaheterocycles through Zn-catalyzed dearomatization of indoles and subsequent base-promoted C–C activation†

Yuanyang Mu,a   Yang Yuan, ORCID logo a   Ye Wang,a   Murong Xu, ORCID logo a   Ye Feng,a   Yulei Zhao ORCID logo *b  and  Yanzhong Li ORCID logo *a  

* Corresponding authors

a School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China
E-mail: yzli@chem.ecnu.edu.cn

b School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong, China
E-mail: zhaoyulei86@126.com

Abstract

A cascade reaction involving the Zn-catalyzed dearomatization of indoles, base-promoted ring-expansion and intramolecular SNAr reaction has been developed. This process realized a novel, atom economical and efficient synthesis of indoline-fused eight-membered azaheterocycles in a one pot manner.

Graphical abstract: Synthesis of indoline-fused eight-membered azaheterocycles through Zn-catalyzed dearomatization of indoles and subsequent base-promoted C–C activation

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Article information

DOI
https://doi.org/10.1039/D0OB01626H
Article type
Paper
Submitted
06 Aug 2020
Accepted
20 Aug 2020
First published
21 Aug 2020

Org. Biomol. Chem., 2020,18, 6916-6926

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Synthesis of indoline-fused eight-membered azaheterocycles through Zn-catalyzed dearomatization of indoles and subsequent base-promoted C–C activation

Y. Mu, Y. Yuan, Y. Wang, M. Xu, Y. Feng, Y. Zhao and Y. Li, Org. Biomol. Chem., 2020, 18, 6916 DOI: 10.1039/D0OB01626H

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