Cu(I)/sucrose-catalyzed hydroxylation of arenes in water: the dual role of sucrose

Kohei Watanabe; Mio Takagi; Ayako Watanabe; Shigeo Murata; Ryo Takita

doi:10.1039/D0OB01683G

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Cu(i)/sucrose-catalyzed hydroxylation of arenes in water: the dual role of sucrose†

Kohei Watanabe,

*^a Mio Takagi,^a Ayako Watanabe,^a Shigeo Murata^a and Ryo Takita

*^a

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* Corresponding authors

^a One-stop Sharing Facility Center for Future Drug Discoveries, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, Japan
E-mail: k-watanabe@mol.f.u-tokyo.ac.jp, takita@mol.f.u-tokyo.ac.jp

Abstract

A protocol for the hydroxylation of aryl halides catalyzed by copper(I) and sucrose in neat water has been developed. The dual role of sucrose, the reaction pathway, and the high selectivity for hydroxylation were investigated using a combination of experimental and theoretical techniques.

This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC

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Article information

DOI: https://doi.org/10.1039/D0OB01683G
Article type: Communication
Submitted: 14 Aug 2020
Accepted: 17 Sep 2020
First published: 17 Sep 2020

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Org. Biomol. Chem., 2020,18, 7827-7831

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Cu(I)/sucrose-catalyzed hydroxylation of arenes in water: the dual role of sucrose

K. Watanabe, M. Takagi, A. Watanabe, S. Murata and R. Takita, Org. Biomol. Chem., 2020, 18, 7827 DOI: 10.1039/D0OB01683G

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Organic & Biomolecular Chemistry

Cu(i)/sucrose-catalyzed hydroxylation of arenes in water: the dual role of sucrose†

Abstract

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Cu(I)/sucrose-catalyzed hydroxylation of arenes in water: the dual role of sucrose

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