Palladium-catalyzed C-glycosylation and annulation of o-alkynylanilines with 1-iodoglycals: convenient access to 3-indolyl-C-glycosides

Abstract

An efficient and practical approach for the synthesis of 3-indolyl-C-Δ^1,2-glycosides through a palladium-catalyzed annulation/C-glycosylation sequence of o-alkynylanilines with 1-iodoglycals has been developed. This methodology has a wide scope of substrates and gives access to 3-indolyl-C-Δ^1,2-glycosides in high yields. Furthermore, the product obtained here exhibits a high utility for further transformations.