Issue 9, 2020

Unusual absence of FRET in triazole bridged coumarin–hydroxyquinoline, an active sensor for Hg2+ detection

Abstract

A triazole-bridged coumarin conjugated quinoline sensor has been ‘click’-synthesized by Cu(I) catalyzed Huisgen cycloaddition, and it exhibited high selectivity for toxic Hg2+. Surprisingly, no evidence of energy transfer from the quinoline moiety to coumarin has been found, substantiated by time-resolved fluorescence study. The possible binding mode of this sensor to Hg2+ has been established via NMR study, steady-state and time-resolved fluorescence spectroscopy, which is further supported by TDDFT calculations. The sensor has been found to be cell membrane permeable and non-toxic, and hence is suitable for intracellular Hg2+ detection.

Graphical abstract: Unusual absence of FRET in triazole bridged coumarin–hydroxyquinoline, an active sensor for Hg2+ detection

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2020
Accepted
08 Jul 2020
First published
29 Jul 2020

Photochem. Photobiol. Sci., 2020,19, 1211-1221

Unusual absence of FRET in triazole bridged coumarin–hydroxyquinoline, an active sensor for Hg2+ detection

S. Mondal, N. Patra, H. P. Nayek, S. K. Hira, S. Chatterjee and S. Dey, Photochem. Photobiol. Sci., 2020, 19, 1211 DOI: 10.1039/D0PP00140F

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