Issue 9, 2020

Covalently assembled ultrathin polymer nanocapsules to mimic a multienzyme-cascade antioxidative system

Abstract

Ultrathin selenium-containing manganese-porphyrin-based polymer nanocapsules with both superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity were successfully constructed through a covalent assembly strategy for mimicking the natural multienzyme-cascade antioxidative system. In this case, Mn-CATPyP (4,4′,4′′,4′′′-(Mn-porphyrin-5,10,15,20-tetrayl)tetrakis (1-(6-carboxyhexyl)pyridin-1-ium)) served as an SOD mimic, while Se-diamine(2,2′-selenobis(ethan-1-amine)) was designed to mimic GPx. The functionalized system shows good biocompatibility for efficient cellular internalization. In vitro experiments also demonstrated the excellent ROS-scavenging ability of the polymer nanocapsules in cell protection against oxidative stress. This artificial cooperative antioxidant model may help us to understand the natural antioxidative process.

Graphical abstract: Covalently assembled ultrathin polymer nanocapsules to mimic a multienzyme-cascade antioxidative system

Supplementary files

Article information

Article type
Research Article
Submitted
12 Jun 2020
Accepted
21 Jul 2020
First published
21 Jul 2020

Mater. Chem. Front., 2020,4, 2797-2804

Covalently assembled ultrathin polymer nanocapsules to mimic a multienzyme-cascade antioxidative system

R. Tian, X. Fan, S. Liu, Y. Xue, F. Yang, F. Li, Q. Luo, J. Xu and J. Liu, Mater. Chem. Front., 2020, 4, 2797 DOI: 10.1039/D0QM00389A

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