Copper-catalysed oxidative α-C(sp3)–H nitroalkylation of (hetero)arene-fused cyclic amines

Xiu Li; He Zhao; Xiuwen Chen; Huanfeng Jiang; Min Zhang

doi:10.1039/C9QO01208G

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Copper-catalysed oxidative α-C(sp³)–H nitroalkylation of (hetero)arene-fused cyclic amines†

Xiu Li,^a He Zhao,^a Xiuwen Chen,

^b Huanfeng Jiang

^a and Min Zhang

*^ab

Author affiliations

* Corresponding authors

^a Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: minzhang@scut.edu.cn

^b School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. China

Abstract

Under aerobic copper catalysis, we herein report a direct α-C(sp³)–H nitroalkylation of N-unsubstituted (hetero)arene-fused cyclic amines with nitroalkanes. The transformation proceeds with good substrate and functional group compatibility, high step and atom efficiency, and operational simplicity.

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Article information

DOI: https://doi.org/10.1039/C9QO01208G
Article type: Research Article
Submitted: 02 Oct 2019
Accepted: 09 Dec 2019
First published: 12 Dec 2019

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Org. Chem. Front., 2020,7, 425-429

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Copper-catalysed oxidative α-C(sp³)–H nitroalkylation of (hetero)arene-fused cyclic amines

X. Li, H. Zhao, X. Chen, H. Jiang and M. Zhang, Org. Chem. Front., 2020, 7, 425 DOI: 10.1039/C9QO01208G

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