Issue 5, 2020

A Rh(iii)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides

Abstract

A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of arylboronic acids, alkynes and CO for the synthesis of butenolides has been developed. The multi-step reaction proceeded smoothly in the presence of [RhCp*Cl2]2 catalyst, NaOAc base and CH3OH additive. The reaction used readily available starting materials, tolerated various functional groups, and afforded valuable butenolides in good yields with high regioselectivity.

Graphical abstract: A Rh(iii)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides

Supplementary files

Article information

Article type
Research Article
Submitted
17 Dec 2019
Accepted
28 Jan 2020
First published
05 Feb 2020

Org. Chem. Front., 2020,7, 763-767

A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides

M. Zhao, Y. Zhang, N. Ge, L. Yu, S. Wang, Z. Ren and Z. Guan, Org. Chem. Front., 2020, 7, 763 DOI: 10.1039/C9QO01486A

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