Palladium-catalyzed domino Heck cyclization/ring opening of sulfolenes/desulfitative coupling: regio- and stereoselective synthesis of alkylated conjugated dienes

Abstract

A novel palladium-catalyzed regio- and stereoselective dienylation via a combination of cascade carbopalladation and subsequent desulfitative coupling after the base-induced ring opening of sulfolenes has been described. In this reaction, a range of Z-selective conjugated dienes bearing oxindoles or isoquinolinediones are obtained in moderate yields.