Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions

Anna Barosi; Petra Dunkel; Erwann Guénin; Yoann Lalatonne; Philippe Zeitoun; Isabelle Fitton; Clément Journé; Alberto Bravin; Antoine Maruani; Hamid Dhimane; Laurence Motte; Peter I. Dalko

doi:10.1039/C9RA09828C

Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions†

Anna Barosi,^a Petra Dunkel,

^a Erwann Guénin,

^bc Yoann Lalatonne,

^bd Philippe Zeitoun,^e Isabelle Fitton,

^f Clément Journé,^b Alberto Bravin,

^g Antoine Maruani,^h Hamid Dhimane,

^a Laurence Motte

*^b and Peter I. Dalko

*^a

Author affiliations

* Corresponding authors

^a Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, UMR 8601, 45, Rue des Saints-Pères, 75210 Paris, France
E-mail: peter.dalko@parisdescartes.fr

^b Laboratory for Vascular Translational Sciences (LVTS), INSERM, U1148, Université Paris 13, 74 Rue Marcel Cachin, 93017 Bobigny, France
E-mail: laurence.motte@univ-paris13.fr

^c Sorbonne University – Université de Technologie de Compiègne, Laboratoire TIMR (UTC/ESCOM), EA4297, Centre de recherche de Royallieu, Rue du Docteur Schweitzer, CS 60319, 60203 Compiègne Cedex, France

^d Services de Biochimie et de Médecine Nucléaire, Hôpital Avicenne Assistance Publique-Hôpitaux de Paris, 125 Rue de Stalingrad, 93009 Bobigny, France

^e Laboratoire d’Optique Appliquée, UMR 7639 ENSTA-ParisTech, CNRS, Institut Polytechnique de Paris, 828 boulevard des Maréchaux, 91120 Palaiseau, France

^f Service de Radiologie Hôpital Européen Georges Pompidou, Paris, France

^g ESRF, ID17 Beamline, 71 Avenue des Martyrs, 38043 Grenoble, France

^h Department of Chemistry, University College London, 20 Gordon Street, London, UK

Abstract

An efficient nano-sized delivery system is presented here allowing the immobilized, picolinium-tethered organic ligand to be released by X-ray irradiation. A marked difference was observed in the fragmentation efficiency by using conventional Cs-137 vs. pulsed sources.

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Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions†

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Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions

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