Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide

Ming Yao; Jingjing Zhang; Sen Yang; Hangxing Xiong; Li Li; E. Liu; Hong Shi

doi:10.1039/D0RA00251H

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Efficient synthesis of 1-iodoalkynes via Al₂O₃ mediated reaction of terminal alkynes and N-iodosuccinimide†

Ming Yao,

*^a Jingjing Zhang,^ab Sen Yang,^a Hangxing Xiong,*^ab Li Li,^ab E. Liu^a and Hong Shi^a

Author affiliations

* Corresponding authors

^a Jingchu University of Technology, 33 Xiangshan Road, Jingmen, Hubei 448000, P. R. China
E-mail: yaomingcep@jcut.edu.cn

^b Wuhan Institute of Technology, 206 Guanggu First Road, Wuhan, Hubei 430205, P. R. China

Abstract

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al₂O₃ was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.

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Article information

DOI: https://doi.org/10.1039/D0RA00251H
Article type: Paper
Submitted: 09 Jan 2020
Accepted: 16 Jan 2020
First published: 23 Jan 2020
This article is Open Access

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RSC Adv., 2020,10, 3946-3950

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Efficient synthesis of 1-iodoalkynes via Al₂O₃ mediated reaction of terminal alkynes and N-iodosuccinimide

M. Yao, J. Zhang, S. Yang, H. Xiong, L. Li, E. Liu and H. Shi, RSC Adv., 2020, 10, 3946 DOI: 10.1039/D0RA00251H

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