Issue 21, 2020

Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

Abstract

The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.

Graphical abstract: Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

Supplementary files

Article information

Article type
Paper
Submitted
10 Feb 2020
Accepted
23 Mar 2020
First published
27 Mar 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 12604-12610

Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

G. Mazzoccanti, S. Manetto, M. Bassan, A. Foschini, A. Orlandin, A. Ricci, W. Cabri, O. H. Ismail, M. Catani, A. Cavazzini and F. Gasparrini, RSC Adv., 2020, 10, 12604 DOI: 10.1039/D0RA01296C

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