Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe3O4/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine

Abstract

The present investigation examines a sensitive electrochemical technique to detect desipramine through Fe₃O₄/CuO nanoparticles (NPs). Fe₃O₄/CuO NPs were synthesized via a coprecipitation procedure, and the products were characterized via energy disperse spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and vibrating sample magnetometer. The voltage–current curve and differential pulse voltammetry examinations of Fe₃O₄/CuO-modified screen-printed electrode (Fe₃O₄/CuO/SPE) were followed by the determination of electro-catalytic activities toward desipramine oxidation in a phosphate buffer solution (pH = 7.0). In addition, the value of diffusion coefficient (D = 3.0 × 10⁻⁶ cm² s⁻¹) for desipramine was calculated. Then, based on the optimum conditions, it was observed that the currents of the oxidation peak were linearly proportionate to the concentration of desipramine in the broad range between 0.08 and 400.0 μM and LOD of 0.03 μM (S/N = 3). Finally, our new sensor was successfully utilized to detect desipramine in the real samples, with reasonable recovery in the range of 97.2% to 102.7%.