Issue 26, 2020
From the journal:

RSC Advances

Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.†

Xintong Hou,ab   Yang Xu,b   Shuaiming Zhu,c   Yang Zhang, ORCID logo *c   Liangdong Guo,d   Feng Qiu ORCID logo a  and  Yongsheng Che*ab  

* Corresponding authors

a Tianjin University of Traditional Chinese Medicine, Tianjin 300193, People's Republic of China

b Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China
E-mail: cheys@im.ac.cn

c State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, People's Republic of China
E-mail: zhangyang@bmi.ac.cn

d State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China

Abstract

Three new highly oxygenated pimarane diterpenoids, sarcosenones A–C (1–3), and the known 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), were isolated from cultures of an endolichenic fungus Sarcosomataceae sp. Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compound 1 showed moderate cytotoxicity against a small panel of four human tumor cell lines, with IC50 values of 7.5–26.4 μM.

Graphical abstract: Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.

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Article information

DOI
https://doi.org/10.1039/D0RA02485F
Article type
Paper
Submitted
17 Mar 2020
Accepted
06 Apr 2020
First published
22 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 15622-15628

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Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.

X. Hou, Y. Xu, S. Zhu, Y. Zhang, L. Guo, F. Qiu and Y. Che, RSC Adv., 2020, 10, 15622 DOI: 10.1039/D0RA02485F

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