An original, facile, and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from ortho-nitrochalcones is described. The featured transformation is a triggered Michael addition of the cyanide anion to the chalcone followed by a cascade cyclization mechanistically related to the Baeyer–Drewson reaction.
N. A. Aksenov, D. A. Aksenov, N. A. Arutiunov, D. S. Aksenova, A. V. Aksenov and M. Rubin, RSC Adv., 2020, 10, 18440 DOI: 10.1039/D0RA03520C
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