Issue 43, 2020, Issue in Progress
From the journal:

RSC Advances

Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

Javier Águila-Rosas,af   Tomás Quirino-Barreda,a   Gerardo Leyva-Gómez,b   Eduardo González-Zamora, ORCID logo c   Ilich A. Ibarra ORCID logo *de  and  Enrique Lima*d  

* Corresponding authors

a Laboratorio de Farmacia Molecular y Liberación Controlada, UAM-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, CDMX, Mexico

b Facultad de Química, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cd. Universitaria, Del. Coyoacán, CP 04510 CDMX, Mexico

c Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Ciudad de México, Mexico

d Laboratorio de Fisicoquímica y Reactividad de Superficies (LaFReS), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cd. Universitaria, Del. Coyoacán, CDMX, Mexico
E-mail: argel@unam.mx, lima@iim.unam.mx
Fax: +52-55-5622-4595

e Pharma View Consulting SC, CDMX, Mexico

f Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, UAM-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Mexico

Abstract

Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine–MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.

Graphical abstract: Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/D0RA03636F
Article type
Paper
Submitted
23 Apr 2020
Accepted
01 Jul 2020
First published
07 Jul 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 25645-25651

Permissions

Request permissions

Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

J. Águila-Rosas, T. Quirino-Barreda, G. Leyva-Gómez, E. González-Zamora, I. A. Ibarra and E. Lima, RSC Adv., 2020, 10, 25645 DOI: 10.1039/D0RA03636F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements