An unprecedented union of multi-component reactions to construct pyrazole- and pyranopyrazole-adorned 4H-chromene from simple reactants in water at ambient temperature is reported. This innovative tactic has integrated two distinct four-component reactions (4CRs) that occur transiently to form four new heterocycles via ten covalent bonds in a single step.
K. Kumaravel, B. Rajarathinam and G. Vasuki, RSC Adv., 2020, 10, 29109 DOI: 10.1039/D0RA05105E
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