Issue 49, 2020
From the journal:

RSC Advances

Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction†

Yuepeng Cao,a   Zhenhua Gao,a   Junchen Li,a   Xiaojing Bi,a   Ling Yuan,a   Chengxin Pei,a   Yongbiao Guo ORCID logo *a  and  Enxue Shi*a  

* Corresponding authors

a State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China
E-mail: van87120@126.com, exshi@sina.com

Abstract

A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates.

Graphical abstract: Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction

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Article information

DOI
https://doi.org/10.1039/D0RA05140C
Article type
Paper
Submitted
11 Jun 2020
Accepted
27 Jul 2020
First published
11 Aug 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 29493-29497

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Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction

Y. Cao, Z. Gao, J. Li, X. Bi, L. Yuan, C. Pei, Y. Guo and E. Shi, RSC Adv., 2020, 10, 29493 DOI: 10.1039/D0RA05140C

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