Issue 41, 2020, Issue in Progress

Total synthesis of quinolactacin-H from marine-derived Penicillium sp. ENP701 and biological activities

Abstract

The quinolactacins are a family of pyrroloquinoline-type natural products from Penicillium sp. From the organic extract of Penicillium sp. ENP701 fermentation broth, a microorganism from the east China sea, one new quinolactacin was isolated and named quinolactacin-H. The structure of quinolactacin-H was determined by spectroscopic analysis and the absolute configurations by X-ray crystallographic analysis. Enantioselective total synthesis of (R)-(+)-quinolactacin-H and (S)-(−)-quinolactacin-H was achieved. When assayed through crystal violet (CV) microtiter plate biofilm, both (R) and (S)-quinolactacin-H showed a strong inhibition and dispersion of Pseudomonas aeruginosa PAO1 biofilms. Thus, quinolactacins could be proposed and developed as natural anti-bioflm agents in order to solve the problem of microbial resistance in future.

Graphical abstract: Total synthesis of quinolactacin-H from marine-derived Penicillium sp. ENP701 and biological activities

Supplementary files

Article information

Article type
Paper
Submitted
01 Jun 2020
Accepted
16 Jun 2020
First published
25 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 24251-24254

Total synthesis of quinolactacin-H from marine-derived Penicillium sp. ENP701 and biological activities

J. Zhu, Y. Lu, J. Chen, J. Chen, H. Zhang, X. Bao, X. Ye and H. Wang, RSC Adv., 2020, 10, 24251 DOI: 10.1039/D0RA05244B

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