It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal–Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).
S. B. Wagh, V. Maslivetc, J. J. La Clair and A. Kornienko, RSC Adv., 2020, 10, 37035 DOI: 10.1039/D0RA06962K
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