Issue 54, 2020
From the journal:

RSC Advances

Lipoic acid capped silver nanoparticles: a facile route to covalent protein capping and oxidative stability within biological systems†

Irene Guzmán-Soto,a   Mary Omole,a   Emilio I. Alarcon ORCID logo *ab  and  Christopher D. McTiernan ORCID logo *a  

* Corresponding authors

a Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Canada
E-mail: ealarcon@ottawaheart.ca, cmctiernan@ottawaheart.ca

b Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada

Abstract

Covalent attachment of human serum albumin protein to the surface of spherical lipoic acid capped silver nanoparticles results in the generation of stable nanoparticle–protein hybrids with well defined surface composition. Enhanced stability towards oxidation and in the presence of complex media with high ionic strength, holds promise towards the use of these conjugates as therapeutics in biomedical applications and sensing.

Graphical abstract: Lipoic acid capped silver nanoparticles: a facile route to covalent protein capping and oxidative stability within biological systems

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Article information

DOI
https://doi.org/10.1039/D0RA07080G
Article type
Paper
Submitted
17 Aug 2020
Accepted
27 Aug 2020
First published
04 Sep 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 32953-32958

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Lipoic acid capped silver nanoparticles: a facile route to covalent protein capping and oxidative stability within biological systems

I. Guzmán-Soto, M. Omole, E. I. Alarcon and C. D. McTiernan, RSC Adv., 2020, 10, 32953 DOI: 10.1039/D0RA07080G

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