Diastereoselective synthesis of CF3-dihydrobenzofurans by [4+1] annulation of in situ-generated CF3-o-quinone methides and sulfur ylides

Abstract

An efficient and highly diastereoselective synthesis of CF₃-dihydrobenzofurans by the reaction of in situ-generated CF₃-oQMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF₃-oQM has been utilized first time for the annulation reaction.