Issue 66, 2020
From the journal:

RSC Advances

Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds†

Willy Carrasquel-Ursulaez,a   Ryan D. Reeves,b   Mahzad Dehghany, ORCID logo b   Corey Jones,b   Jennifer M. Schomaker ORCID logo *b  and  Baron Chanda*a  

* Corresponding authors

a Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA
E-mail: bchanda@wustl.edu

b Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
E-mail: schomakerj@chem.wisc.edu

Abstract

The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores.

Graphical abstract: Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds

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Article information

DOI
https://doi.org/10.1039/D0RA08494H
Article type
Paper
Submitted
06 Oct 2020
Accepted
30 Oct 2020
First published
05 Nov 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 40391-40394

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Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds

W. Carrasquel-Ursulaez, R. D. Reeves, M. Dehghany, C. Jones, J. M. Schomaker and B. Chanda, RSC Adv., 2020, 10, 40391 DOI: 10.1039/D0RA08494H

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