One-for-all intelligent core–shell nanoparticles for tumor-specific photothermal–chemodynamic synergistic therapy

Abstract

Reasonable management of the one-for-all nanoplatform can facilitate improved cancer therapy. Here, the metal–organic frameworks (MOFs) based on iron(III) carboxylate material (MIL-101-NH₂) were in situ decorated on stabilized polydopamine nanoparticles (PDANPs), which subsequently loaded glucose oxidase (GOx) via hyaluronic acid (HA) coating to structure the one-for-all intelligent core–shell nanoparticles (HG-MIL@PDANPs). Because of the inner PDANPs, the HG-MIL@PDANPs could realize near-infrared (NIR)-controllable site-specific photothermal therapy (PTT). Additionally, the core–shell nanoparticles exhibited a pH-triggered and NIR-reinforced release of Fe³⁺ and GOx owing to the controllable degradation of the outer shell. Hydroxyl radicals (˙OH) were produced for chemodynamic therapy (CDT) employing the Fe²⁺-driven Fenton reaction, which could be greatly promoted by Fe³⁺-involved glutathione (GSH) depletion and GOx-catalyzed acidity recovery and H₂O₂ self-sufficiency. Moreover, the HA ligand could enhance the tumor accumulation of the HG-MIL@PDANPs through the long blood circulation time and CD44-targeted cell recognition. The ingenious integration of PTT and CDT in one fully equipped system presented excellent synergistic antitumor efficiency in vitro and in vivo with favorable biosafety. The one-for-all intelligent core–shell nanoparticles with CD44 targeting provide a new avenue for engineering on-demand tumor-specific therapy.