Issue 7, 2021

Recent research progress in the construction of active free radical nanoreactors and their applications in photodynamic therapy

Abstract

Photodynamic therapy is the most important treatment strategy in free radical therapy. However, tumor microenvironment hypoxia is a key obstacle in PDT. In order to overcome this obstacle, the strategy of in situ production of O2/radicals by catalytic reaction in solid tumors was proposed. In recent years, it has been found that there are many oxygen-independent carbon-based free radicals that can generate toxic active free radicals under laser irradiation and lead to tumor cell death. Based on the rational design of multifunctional nano-medicine, the active free radical nano-generator has opened up a new way for the highly developed nanotechnology and tumor cooperative therapy to improve the therapeutic effect. In this paper, the research status of active free radical nano-generators, especially reactive oxygen species, including the construction mechanism of active free radical nanomaterials, is reviewed and the application of free radical nano-generators in tumor therapy is emphasized.

Graphical abstract: Recent research progress in the construction of active free radical nanoreactors and their applications in photodynamic therapy

Article information

Article type
Review Article
Submitted
26 Nov 2020
Accepted
27 Jan 2021
First published
28 Jan 2021

Biomater. Sci., 2021,9, 2384-2412

Recent research progress in the construction of active free radical nanoreactors and their applications in photodynamic therapy

J. Xiao, H. Cong, S. Wang, B. Yu and Y. Shen, Biomater. Sci., 2021, 9, 2384 DOI: 10.1039/D0BM02013C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements