Versatile fluorinated Pd@Au nanoplates doped with yttrium for tumor theranostics

Abstract

As one of the emerging modalities of magnetic resonance imaging (MRI), ¹⁹F MRI is highly conducive for the specific detection and imaging of deep-seated tumors, with negligible background. However, most ¹⁹F MRI probe designs are constructed with organic CF₃, which contains rich fluorine atoms, and few of the fluorine-containing groups are equipped with therapeutic function. Herein, we designed a versatile ¹⁹F MRI-based theranostic nanoplatform, FY-Pd@Au nano-metallacages (FY-Pd@Au NCs), which not only serve as a ¹⁹F MRI/CT/PAI contrast agent, but also produce reactive oxygen species (ROS) by type I photodynamic therapy (PDT) pathway, as well as heat for photothermal therapy (PTT), under the single NIR laser irradiation. Overall, this work successfully built a theranostics nanoplatform based on ¹⁹F MRI.