Issue 2, 2021

Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

Abstract

Rising bacterial antibiotic resistance is a global threat. To deal with it, new antibacterial agents and antiseptic materials need to be developed. One alternative in this quest is the organometallic derivatization of well-established antibacterial drugs and also the fabrication of advanced metal-based materials having antibacterial properties. Metal-based agents and materials often show new modes of antimicrobial action which enable them to overcome drug resistance in pathogenic bacterial strains. This review summarizes recent (2017–2020) progress in the field of organometallic-derived antibacterial drugs and metal-based materials having antibacterial activity. Specifically, it covers organometallic derivatives of antibacterial drugs including β-lactams, ciprofloxacin, isoniazid, trimethoprim, sulfadoxine, sulfamethoxazole, and ethambutol as well as non-antibacterial drugs like metformin, phenformin and aspirin. Recent advances and reported clinical trials in the use of metal-based nanomaterials as antibiofouling coatings on medical devices, as photocatalytic agents in indoor air pollutant control, and also as photodynamic/photothermal antimicrobial agents are also summarized.

Graphical abstract: Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

Article information

Article type
Review Article
Submitted
26 Nov 2020
Accepted
04 Jan 2021
First published
26 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 368-386

Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

P. Biegański, Ł. Szczupak, M. Arruebo and K. Kowalski, RSC Chem. Biol., 2021, 2, 368 DOI: 10.1039/D0CB00218F

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