Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe

Junyong Wu; Anyao Bi; Fan Zheng; Shuai Huang; Yongjiang Li; Jipeng Ding; Daxiong Xiang; Wenbin Zeng

doi:10.1039/D0CC07289C

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Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe†

Junyong Wu,‡^a Anyao Bi,‡^b Fan Zheng,^b Shuai Huang,^b Yongjiang Li,^a Jipeng Ding,

^b Daxiong Xiang*^a and Wenbin Zeng

*^b

Author affiliations

* Corresponding authors

^a Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China
E-mail: xiangdaxiong@csu.edu.cn

^b Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, P. R. China
E-mail: wbzeng@hotmail.com

Abstract

We herein developed a novel tetraarylimidazole-based AIE probe TPIG-NP to selectively image and quantitatively detect glioma. Due to the distinct negatively charged glioma cells, TPIG-NP with an opposite charge could achieve wash-free imaging of glioma cells and 3D multicellular spheroids.

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Article information

DOI: https://doi.org/10.1039/D0CC07289C
Article type: Communication
Submitted: 04 Nov 2020
Accepted: 11 Dec 2020
First published: 17 Dec 2020

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Chem. Commun., 2021,57, 801-804

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Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe

J. Wu, A. Bi, F. Zheng, S. Huang, Y. Li, J. Ding, D. Xiang and W. Zeng, Chem. Commun., 2021, 57, 801 DOI: 10.1039/D0CC07289C

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Chemical Communications

Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe†

Abstract

Supplementary files

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Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe

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