Issue 30, 2021

Palladium-catalyzed decarbonylative and decarboxylative cross-coupling of acyl chlorides with potassium perfluorobenzoates affording unsymmetrical biaryls

Abstract

This paper describes the synthesis of unsymmetrical biaryls by the palladium-catalyzed cross-coupling reaction of acyl chlorides with potassium perfluorobenzoates. This transformation is unique in that it involves simultaneous decarbonylation and decarboxylation under redox-neutral conditions. Compared to conventional cross-coupling protocols for the synthesis of unsymmetrical biaryls, the two reactants in this synthetic strategy can be readily prepared from abundant and inexpensive aromatic carboxylic acids.

Graphical abstract: Palladium-catalyzed decarbonylative and decarboxylative cross-coupling of acyl chlorides with potassium perfluorobenzoates affording unsymmetrical biaryls

Supplementary files

Article information

Article type
Communication
Submitted
12 Jan 2021
Accepted
11 Mar 2021
First published
11 Mar 2021

Chem. Commun., 2021,57, 3696-3699

Palladium-catalyzed decarbonylative and decarboxylative cross-coupling of acyl chlorides with potassium perfluorobenzoates affording unsymmetrical biaryls

L. Fu, J. You and Y. Nishihara, Chem. Commun., 2021, 57, 3696 DOI: 10.1039/D1CC00202C

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