Photo-induced mitochondrial DNA damage and NADH depletion by –NO2 modified Ru(II) complexes

Shuang Qi; Zhihui Jin; Yao Jian; Yuanjun Hou; Chao Li; Yao Zhao; Xuesong Wang; Qianxiong Zhou

doi:10.1039/D1CC00258A

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Photo-induced mitochondrial DNA damage and NADH depletion by –NO₂ modified Ru(ii) complexes†

Shuang Qi,‡^ab Zhihui Jin,

‡^ab Yao Jian,^ab Yuanjun Hou,^a Chao Li,^a Yao Zhao,

*^c Xuesong Wang

*^ab and Qianxiong Zhou

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, zhouqianxiong@mail.ipc.ac.cn
Fax: +86-10-62564049
Tel: +86-10-82543592

^b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

^c CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: yaozhao@iccas.ac.cn

Abstract

Two mitochondria-localized Ru(II) complexes with photo-labile ligands were reported to exert one- and two-photon activatable anticancer activity through a dual-function mechanism, i.e. mitochondrial DNA covalent binding after photo-induced ligand dissociation and photo-catalyzed NADH depletion, thus displaying good activity towards cisplatin-resistant cancer cells under both normoxic and hypoxic conditions.

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Article information

DOI: https://doi.org/10.1039/D1CC00258A
Article type: Communication
Submitted: 15 Jan 2021
Accepted: 17 Mar 2021
First published: 17 Mar 2021

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Chem. Commun., 2021,57, 4162-4165

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Photo-induced mitochondrial DNA damage and NADH depletion by –NO₂ modified Ru(II) complexes

S. Qi, Z. Jin, Y. Jian, Y. Hou, C. Li, Y. Zhao, X. Wang and Q. Zhou, Chem. Commun., 2021, 57, 4162 DOI: 10.1039/D1CC00258A

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Chemical Communications