Issue 25, 2021
From the journal:

Chemical Communications

A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy†

Yanqing Li,‡a   Chongchong Wang,‡a   Lin Zhou ORCID logo *a  and  Shaohua Wei ORCID logo *ab  

* Corresponding authors

a College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, Jiangsu 210023, China
E-mail: zhoulin@njnu.edu.cn, shwei@njnu.edu.cn

b School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China

Abstract

A 2-pyridone modified zinc phthalocyanine (denoted ZnPc-PYR) achieves a one stone for three birds outcome in the photodynamic therapy (PDT) treatment of cancer. ZnPc-PYR can be excited by both 665 and 808 nm light to treat superficial and deep tumors, store and slowly release singlet oxygen (1O2) to improve its utilization and downregulate the HIF-1 (hypoxia-inducible factor 1) expression level to enhance the tumor cell's sensitivity to PDT treatment under hypoxic conditions.

Graphical abstract: A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D1CC00645B
Article type
Communication
Submitted
03 Feb 2021
Accepted
12 Feb 2021
First published
13 Feb 2021

Chem. Commun., 2021,57, 3127-3130

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A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy

Y. Li, C. Wang, L. Zhou and S. Wei, Chem. Commun., 2021, 57, 3127 DOI: 10.1039/D1CC00645B

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