Issue 45, 2021
From the journal:

Chemical Communications

Ultrasensitive homogeneous detection of microRNAs in a single cell with specifically designed exponential amplification†

Kejian Gao,a   Pengbo Zhang, ORCID logo a   Hui Wang, ORCID logo a   Honghong Wang, ORCID logo a   Fengxia Su ORCID logo a  and  Zhengping Li ORCID logo *a  

* Corresponding authors

a Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083, P. R. China
E-mail: lzpbd@ustb.edu.cn

Abstract

We firstly developed an ultrasensitive method based on specifically designed exponential amplification for miRNA detection with simple operation in homogeneous solutions. The proposed assay can detect miRNAs at a concentration as low as 1 aM and can be successfully applied for routine miRNA detection in a single cell.

Graphical abstract: Ultrasensitive homogeneous detection of microRNAs in a single cell with specifically designed exponential amplification

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Article information

DOI
https://doi.org/10.1039/D1CC01326B
Article type
Communication
Submitted
11 Mar 2021
Accepted
21 Apr 2021
First published
21 Apr 2021

Chem. Commun., 2021,57, 5570-5573

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Ultrasensitive homogeneous detection of microRNAs in a single cell with specifically designed exponential amplification

K. Gao, P. Zhang, H. Wang, H. Wang, F. Su and Z. Li, Chem. Commun., 2021, 57, 5570 DOI: 10.1039/D1CC01326B

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